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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

It is an autologous blood product, meaning it is made from the patient's own blood drawn and centrifuged on-site

The researchers utilized standardized scoring systems to quantify cartilage damage, assessing factors including surface irregularity, structural disorganization, and cellular changes

GHK-Cu cycling - typically 30 days on / 14 off or 8 weeks on / 4 off - produces comparable results, reduces cost, limits theoretical copper load and keeps receptor sensitivity fresh

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